This article highlights the need for Cooperative Extension to increase awareness of Tribal concerns around activities that impact land, natural resources, and water. A research team at UC Berkeley worked with a Tribal Advisory Committee to conduct a survey of Tribal representatives’ perceptions of cannabis impacts on Native lands and cultural resources. The results show that there is widespread concern among Native communities about the environmental impacts of cannabis cultivation, especially to water quality, access, and availability. These concerns underscore the need to include Native communities in Extension’s agricultural and natural resource activities across all regions and sectors.